6GU2

CDK1/CyclinB/Cks2 in complex with Flavopiridol

6GU2 の概要

• エントリーDOI: 10.2210/pdb6gu2/pdb
• 分子名称: Cyclin-dependent kinase 1, G2/mitotic-specific cyclin-B1, Cyclin-dependent kinases regulatory subunit 2, ... (5 entities in total)
• 機能のキーワード: cdk1, cyclinb1, cks2, inhibitor, cell cycle
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 76616.22

構造登録者

Wood, D.J.,Korolchuk, S.,Tatum, N.J.,Wang, L.Z.,Endicott, J.A.,Noble, M.E.M.,Martin, M.P. (登録日: 2018-06-19, 公開日: 2018-12-05, 最終更新日: 2024-01-17)

• 主引用文献: Wood, D.J.,Korolchuk, S.,Tatum, N.J.,Wang, L.Z.,Endicott, J.A.,Noble, M.E.M.,Martin, M.P.; Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.; Cell Chem Biol, 26:121-130.e5, 2019; PubMed: 30472117; DOI: 10.1016/j.chembiol.2018.10.015

実験手法

X-RAY DIFFRACTION (2 Å)