6GTX

Crystal structure of the FimH lectin domain from E.coli K12 in complex with the dimannoside Man(alpha1-2)Man

6GTX の概要

• エントリーDOI: 10.2210/pdb6gtx/pdb
• 分子名称: Type 1 fimbrin D-mannose specific adhesin, alpha-D-mannopyranose-(1-2)-methyl alpha-D-mannopyranoside, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: type i pilus, catch-bond, cell adhesion, lectin, upec, infection, mannose
• 由来する生物種: Escherichia coli (strain K12)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 69284.73

構造登録者

Jakob, R.P.,Sauer, M.M.,Luber, T.,Canonica, F.,Navarra, G.,Ernst, B.,Unverzagt, C.,Maier, T.,Glockshuber, R. (登録日: 2018-06-19, 公開日: 2019-01-16, 最終更新日: 2024-01-17)

• 主引用文献: Sauer, M.M.,Jakob, R.P.,Luber, T.,Canonica, F.,Navarra, G.,Ernst, B.,Unverzagt, C.,Maier, T.,Glockshuber, R.; Binding of the Bacterial Adhesin FimH to Its Natural, Multivalent High-Mannose Type Glycan Targets.; J.Am.Chem.Soc., 141:936-944, 2019; PubMed: 30543411; DOI: 10.1021/jacs.8b10736

実験手法

X-RAY DIFFRACTION (2.5 Å)