6GTC
Transition state structure of Cpf1(Cas12a) I1 conformation
Summary for 6GTC
Entry DOI | 10.2210/pdb6gtc/pdb |
EMDB information | 0061 |
Descriptor | CRISPR-associated endonuclease Cas12a, RNA (28-MER), DNA (5'-D(P*TP*GP*AP*CP*TP*TP*CP*TP*CP*TP*AP*AP*CP*AP*AP*GP*CP*TP*CP*G)-3'), ... (4 entities in total) |
Functional Keywords | genome editing crispr ribonucleoprotein complex, hydrolase |
Biological source | Francisella tularensis subsp. novicida U112 More |
Total number of polymer chains | 4 |
Total formula weight | 203280.74 |
Authors | Mesa, P.,Montoya, G. (deposition date: 2018-06-18, release date: 2018-12-19, Last modification date: 2019-12-11) |
Primary citation | Stella, S.,Mesa, P.,Thomsen, J.,Paul, B.,Alcon, P.,Jensen, S.B.,Saligram, B.,Moses, M.E.,Hatzakis, N.S.,Montoya, G. Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity. Cell, 175:1856-1871.e21, 2018 Cited by PubMed: 30503205DOI: 10.1016/j.cell.2018.10.045 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.91 Å) |
Structure validation
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