6GQK
Crystal structure of human c-KIT kinase domain in complex with AZD3229-analogue (compound 23)
6GQK の概要
エントリーDOI | 10.2210/pdb6gqk/pdb |
分子名称 | Mast/stem cell growth factor receptor Kit, ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide (3 entities in total) |
機能のキーワード | receptor tyrosine kinase, inhibitor, oncology, gastrointestinal stromal tumour, structure-based drug design, signaling protein |
由来する生物種 | Homo sapiens (Human) 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 75532.08 |
構造登録者 | Schimpl, M.,Hardy, C.J.,Ogg, D.J.,Overman, R.C.,Packer, M.J.,Kettle, J.G.,Anjum, R.,Barry, E.,Bhavsar, D.,Brown, C.,Campbell, A.,Goldberg, K.,Grondine, M.,Guichard, S.,Hunt, T.,Jones, O.,Li, X.,Moleva, O.,Pearson, S.,Shao, W.,Smith, A.,Smith, J.,Stead, D.,Stokes, S.,Tucker, M.,Ye, Y. (登録日: 2018-06-07, 公開日: 2018-09-19, 最終更新日: 2018-10-31) |
主引用文献 | Kettle, J.G.,Anjum, R.,Barry, E.,Bhavsar, D.,Brown, C.,Boyd, S.,Campbell, A.,Goldberg, K.,Grondine, M.,Guichard, S.,Hardy, C.J.,Hunt, T.,Jones, R.D.O.,Li, X.,Moleva, O.,Ogg, D.,Overman, R.C.,Packer, M.J.,Pearson, S.,Schimpl, M.,Shao, W.,Smith, A.,Smith, J.M.,Stead, D.,Stokes, S.,Tucker, M.,Ye, Y. Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors. J. Med. Chem., 61:8797-8810, 2018 Cited by PubMed: 30204441DOI: 10.1021/acs.jmedchem.8b00938 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.31 Å) |
構造検証レポート
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