6GPF

Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112A in complex with AMPPNP

Summary for 6GPF

Entry DOI	10.2210/pdb6gpf/pdb
Related	6GP4 6GP8
Descriptor	Heat shock protein HSP 90-alpha, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	chaperone, hsp90, ntd, alpha, k112a, amppnp, complex, nucleotide
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29269.85
Authors	Tassone, G.,Pozzi, C.,Mangani, S.,Botta, M. (deposition date: 2018-06-05, release date: 2018-10-03, Last modification date: 2024-01-17)
Primary citation	Tassone, G.,Mangani, S.,Botta, M.,Pozzi, C. Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart. Biochim Biophys Acta Proteins Proteom, 1866:1190-1198, 2018 Cited by PubMed: 30248409 DOI: 10.1016/j.bbapap.2018.09.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation