6GOU
Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I
Summary for 6GOU
Entry DOI | 10.2210/pdb6gou/pdb |
Related | 5ADZ |
Descriptor | Alkyldihydroxyacetonephosphate synthase, peroxisomal, FLAVIN-ADENINE DINUCLEOTIDE, (3~{S})-3-[2,6-bis(fluoranyl)phenyl]-~{N}-[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl)methyl]butanamide (3 entities in total) |
Functional Keywords | ether phospholipids, catalytic mechanism, inhibitor, anti-cancer, flavoprotein |
Biological source | Cavia porcellus (Guinea pig) |
Total number of polymer chains | 4 |
Total formula weight | 295933.01 |
Authors | Mattevi, A.,Piano, V. (deposition date: 2018-06-04, release date: 2019-01-02, Last modification date: 2024-01-17) |
Primary citation | Stazi, G.,Battistelli, C.,Piano, V.,Mazzone, R.,Marrocco, B.,Marchese, S.,Louie, S.M.,Zwergel, C.,Antonini, L.,Patsilinakos, A.,Ragno, R.,Viviano, M.,Sbardella, G.,Ciogli, A.,Fabrizi, G.,Cirilli, R.,Strippoli, R.,Marchetti, A.,Tripodi, M.,Nomura, D.K.,Mattevi, A.,Mai, A.,Valente, S. Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells. Eur J Med Chem, 163:722-735, 2018 Cited by PubMed: 30576903DOI: 10.1016/j.ejmech.2018.11.050 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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