6GOU

Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I

6GOU の概要

• エントリーDOI: 10.2210/pdb6gou/pdb
• 関連するPDBエントリー: 5ADZ
• 分子名称: Alkyldihydroxyacetonephosphate synthase, peroxisomal, FLAVIN-ADENINE DINUCLEOTIDE, (3~{S})-3-[2,6-bis(fluoranyl)phenyl]-~{N}-[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl)methyl]butanamide (3 entities in total)
• 機能のキーワード: ether phospholipids, catalytic mechanism, inhibitor, anti-cancer, flavoprotein
• 由来する生物種: Cavia porcellus (Guinea pig)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 295933.01

構造登録者

Mattevi, A.,Piano, V. (登録日: 2018-06-04, 公開日: 2019-01-02, 最終更新日: 2024-01-17)

• 主引用文献: Stazi, G.,Battistelli, C.,Piano, V.,Mazzone, R.,Marrocco, B.,Marchese, S.,Louie, S.M.,Zwergel, C.,Antonini, L.,Patsilinakos, A.,Ragno, R.,Viviano, M.,Sbardella, G.,Ciogli, A.,Fabrizi, G.,Cirilli, R.,Strippoli, R.,Marchetti, A.,Tripodi, M.,Nomura, D.K.,Mattevi, A.,Mai, A.,Valente, S.; Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells.; Eur J Med Chem, 163:722-735, 2018; PubMed: 30576903; DOI: 10.1016/j.ejmech.2018.11.050

実験手法

X-RAY DIFFRACTION (2.9 Å)