6GNH
Crystal Structure of Leishmania major N-Myristoyltransferase (NMT) With Bound Myristoyl-CoA and an Azepanyl Phenyl Benzylsulphonamide Ligand
6GNH の概要
エントリーDOI | 10.2210/pdb6gnh/pdb |
分子名称 | Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, methyl 4-(azepan-1-yl)-3-[(4-methoxyphenyl)sulfonylamino]benzoate, ... (4 entities in total) |
機能のキーワード | acyltransferase, transferase, drug discovery |
由来する生物種 | Leishmania major |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 51909.65 |
構造登録者 | Robinson, D.A.,Harrison, J.R.,Brand, S.,Smith, V.C.,Thompson, S.,Smith, A.,Davies, K.,Mok, N.Y.,Torrie, L.S.,Collie, I.,Hallyburton, I.,Norval, S.,Simeons, F.R.C.,Stojanovski, L.,Frearson, J.A.,Brenk, R.,Wyatt, P.G.,Gilbert, I.H.,Read, K.D. (登録日: 2018-05-30, 公開日: 2018-09-26, 最終更新日: 2024-01-17) |
主引用文献 | Harrison, J.R.,Brand, S.,Smith, V.,Robinson, D.A.,Thompson, S.,Smith, A.,Davies, K.,Mok, N.,Torrie, L.S.,Collie, I.,Hallyburton, I.,Norval, S.,Simeons, F.R.C.,Stojanovski, L.,Frearson, J.A.,Brenk, R.,Wyatt, P.G.,Gilbert, I.H.,Read, K.D. A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors. J. Med. Chem., 61:8374-8389, 2018 Cited by PubMed: 30207721DOI: 10.1021/acs.jmedchem.8b00884 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.89 Å) |
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