6GK0

HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH CLASS III HISTONE DEACETYLASE INHIBITOR

6GK0 の概要

• エントリーDOI: 10.2210/pdb6gk0/pdb
• 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, ... (10 entities in total)
• 機能のキーワード: dehydrogenase dhodh tumor-killing drug development, antitumor protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41975.04

構造登録者

Hakansson, M.,Ladds, M.J.G.W.,Walse, B.,Lain, S. (登録日: 2018-05-17, 公開日: 2019-11-27, 最終更新日: 2024-05-15)

• 主引用文献: Ladds, M.J.G.W.,Popova, G.,Pastor-Fernandez, A.,Kannan, S.,van Leeuwen, I.M.M.,Hakansson, M.,Walse, B.,Tholander, F.,Bhatia, R.,Verma, C.S.,Lane, D.P.,Lain, S.; Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology.; J.Biol.Chem., 295:17935-17949, 2020; PubMed: 32900849; DOI: 10.1074/jbc.RA119.012056

実験手法

X-RAY DIFFRACTION (1.85 Å)