6GJW

Structure of XIAP-BIR1 domain in complex with an NF023 analog

Summary for 6GJW

• Entry DOI: 10.2210/pdb6gjw/pdb
• Descriptor: E3 ubiquitin-protein ligase XIAP, ZINC ION, 4-[[3-[[3-[(4,8-disulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoylamino]phenyl]carbonylamino]naphthalene-1,5-disulfonate, ... (4 entities in total)
• Functional Keywords: bir; nf-kb; xiap; cancer; apoptosis; docking; inhibitor, apoptosis
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 51426.23

Authors

Sorrentino, L.,Cossu, F.,Malkoc, B.,Zaffaroni, M.,Milani, M.,Mastrangelo, E. (deposition date: 2018-05-17, release date: 2019-05-29, Last modification date: 2024-01-17)

• Primary citation: Sorrentino, L.,Cossu, F.,Milani, M.,Malkoc, B.,Huang, W.C.,Tsay, S.C.,Ru Hwu, J.,Mastrangelo, E.; Structure-Activity Relationship of NF023 Derivatives Binding to XIAP-BIR1.; Chemistryopen, 8:476-482, 2019; PubMed: 31011505; DOI: 10.1002/open.201900059

Experimental method

X-RAY DIFFRACTION (1.9 Å)