6GJW

Structure of XIAP-BIR1 domain in complex with an NF023 analog

6GJW の概要

• エントリーDOI: 10.2210/pdb6gjw/pdb
• 分子名称: E3 ubiquitin-protein ligase XIAP, ZINC ION, 4-[[3-[[3-[(4,8-disulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoylamino]phenyl]carbonylamino]naphthalene-1,5-disulfonate, ... (4 entities in total)
• 機能のキーワード: bir; nf-kb; xiap; cancer; apoptosis; docking; inhibitor, apoptosis
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 51426.23

構造登録者

Sorrentino, L.,Cossu, F.,Malkoc, B.,Zaffaroni, M.,Milani, M.,Mastrangelo, E. (登録日: 2018-05-17, 公開日: 2019-05-29, 最終更新日: 2024-01-17)

• 主引用文献: Sorrentino, L.,Cossu, F.,Milani, M.,Malkoc, B.,Huang, W.C.,Tsay, S.C.,Ru Hwu, J.,Mastrangelo, E.; Structure-Activity Relationship of NF023 Derivatives Binding to XIAP-BIR1.; Chemistryopen, 8:476-482, 2019; PubMed: 31011505; DOI: 10.1002/open.201900059

実験手法

X-RAY DIFFRACTION (1.9 Å)