6GJG
Plasmodium falciparum dihydroorotate dehydrogenase DHODH in complex with 3,6-dimethyl-N-(4-(trifluoromethyl)phenyl)-(1,2)oxazolo(5,4-d)pyrimidin-4-amine
Summary for 6GJG
Entry DOI | 10.2210/pdb6gjg/pdb |
Descriptor | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (5 entities in total) |
Functional Keywords | enzyme, dhodh, flavoprotein |
Biological source | Plasmodium falciparum (isolate 3D7) |
Total number of polymer chains | 2 |
Total formula weight | 92613.23 |
Authors | Rowland, P. (deposition date: 2018-05-16, release date: 2018-09-19, Last modification date: 2024-05-15) |
Primary citation | Kokkonda, S.,El Mazouni, F.,White, K.L.,White, J.,Shackleford, D.M.,Lafuente-Monasterio, M.J.,Rowland, P.,Manjalanagara, K.,Joseph, J.T.,Garcia-Perez, A.,Fernandez, J.,Gamo, F.J.,Waterson, D.,Burrows, J.N.,Palmer, M.J.,Charman, S.A.,Rathod, P.K.,Phillips, M.A. Isoxazolopyrimidine-Based Inhibitors ofPlasmodium falciparumDihydroorotate Dehydrogenase with Antimalarial Activity. ACS Omega, 3:9227-9240, 2018 Cited by PubMed: 30197997DOI: 10.1021/acsomega.8b01573 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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