6GJG

Plasmodium falciparum dihydroorotate dehydrogenase DHODH in complex with 3,6-dimethyl-N-(4-(trifluoromethyl)phenyl)-(1,2)oxazolo(5,4-d)pyrimidin-4-amine

6GJG の概要

• エントリーDOI: 10.2210/pdb6gjg/pdb
• 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (5 entities in total)
• 機能のキーワード: enzyme, dhodh, flavoprotein
• 由来する生物種: Plasmodium falciparum (isolate 3D7)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 92613.23

構造登録者

Rowland, P. (登録日: 2018-05-16, 公開日: 2018-09-19)

• 主引用文献: Kokkonda, S.,El Mazouni, F.,White, K.L.,White, J.,Shackleford, D.M.,Lafuente-Monasterio, M.J.,Rowland, P.,Manjalanagara, K.,Joseph, J.T.,Garcia-Perez, A.,Fernandez, J.,Gamo, F.J.,Waterson, D.,Burrows, J.N.,Palmer, M.J.,Charman, S.A.,Rathod, P.K.,Phillips, M.A.; Isoxazolopyrimidine-Based Inhibitors ofPlasmodium falciparumDihydroorotate Dehydrogenase with Antimalarial Activity.; ACS Omega, 3:9227-9240, 2018; PubMed: 30197997; DOI: 10.1021/acsomega.8b01573

実験手法

X-RAY DIFFRACTION (1.99 Å)