6GIM
Structure of the DNA duplex d(AAATTT)2 with [N-(3-chloro-4-((4,5-dihydro-1H-imidazol-2-yl)amino)phenyl)-4-((4,5-dihydro-1H-imidazol-2- yl)amino)benzamide] - (drug JNI18)
6GIM の概要
エントリーDOI | 10.2210/pdb6gim/pdb |
分子名称 | DNA (5'-D(*AP*AP*AP*TP*TP*T)-3'), [4-[(3-chloranyl-4-imidazolidin-2-ylideneazaniumyl-phenyl)carbamoyl]phenyl]-imidazolidin-2-ylidene-azanium, MAGNESIUM ION, ... (4 entities in total) |
機能のキーワード | at-rich dna, dna binding drugs, minor groove binding drugs, antiparasitic drugs, trypanosoma brucei, dna |
由来する生物種 | Trypanosoma brucei |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 8501.51 |
構造登録者 | Millan, C.R.,Dardonvile, C.,de Koning, H.P.,Saperas, N.,Campos, J.L. (登録日: 2018-05-14, 公開日: 2018-08-08, 最終更新日: 2024-05-01) |
主引用文献 | Millan, C.R.,Acosta-Reyes, F.J.,Lagartera, L.,Ebiloma, G.U.,Lemgruber, L.,Nue Martinez, J.J.,Saperas, N.,Dardonville, C.,de Koning, H.P.,Campos, J.L. Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast. Nucleic Acids Res., 45:8378-8391, 2017 Cited by PubMed: 28637278DOI: 10.1093/nar/gkx521 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.43 Å) |
構造検証レポート
検証レポート(詳細版)
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