6GII
The crystal structure of Tepidiphilus thermophilus P450 heme domain
Summary for 6GII
| Entry DOI | 10.2210/pdb6gii/pdb |
| Descriptor | Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total) |
| Functional Keywords | cytochrome p450 class vii, oxidoreductase |
| Biological source | Tepidiphilus thermophilus |
| Total number of polymer chains | 1 |
| Total formula weight | 55562.46 |
| Authors | Levy, C.W. (deposition date: 2018-05-11, release date: 2018-05-30, Last modification date: 2024-01-17) |
| Primary citation | Tavanti, M.,Porter, J.L.,Levy, C.W.,Gomez Castellanos, J.R.,Flitsch, S.L.,Turner, N.J. The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s. Biochem. Biophys. Res. Commun., 501:846-850, 2018 Cited by PubMed Abstract: The first crystal structure of a class VII P450, CYP116B46 from Tepidiphilus thermophilus, has been solved at 1.9 Å resolution. The structure reveals overall conservation of the P450-fold and a water conduit around the I-helix. Active site residues have been identified and sequence comparisons have been made with other class VII enzymes. A structure similarity search demonstrated that the P450-TT structure is similar to enzymes capable of oxy-functionalization of fatty acids, terpenes, macrolides, steroids and statins. The insight gained from solving this structure will provide a guideline for future engineering and modelling studies on this catalytically promiscuous class of enzymes. PubMed: 29738765DOI: 10.1016/j.bbrc.2018.05.014 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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