6GHK

Human PARP1 (ARTD1) - Catalytic domain in complex with inhibitor ME0527

Summary for 6GHK

• Entry DOI: 10.2210/pdb6ghk/pdb
• Descriptor: Poly [ADP-ribose] polymerase 1, ~{N}-[(1~{R})-1-(4-imidazol-1-ylphenyl)ethyl]-3-(4-oxidanylidene-1~{H}-quinazolin-2-yl)propanamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: inhibitor, adp-ribosyl transferase, protein-ligand complex, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 81751.14

Authors

Karlberg, T.,Thorsell, A.G.,Lindgren, A.E.G.,Moche, M.,Brock, J.,Ekblad, T.,Spjut, S.,Elofsson, M.,Schuler, H. (deposition date: 2018-05-08, release date: 2019-05-22, Last modification date: 2024-01-17)

• Primary citation: Karlberg, T.,Thorsell, A.G.,Lindgren, A.E.G.,Ekblad, T.,Spjut, S.,Elofsson, M.,Schuler, H.; Human PARP1 (ARTD1) - Catalytic domain in complex with inhibitor ME0527; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.28 Å)