6GHK

Human PARP1 (ARTD1) - Catalytic domain in complex with inhibitor ME0527

6GHK の概要

• エントリーDOI: 10.2210/pdb6ghk/pdb
• 分子名称: Poly [ADP-ribose] polymerase 1, ~{N}-[(1~{R})-1-(4-imidazol-1-ylphenyl)ethyl]-3-(4-oxidanylidene-1~{H}-quinazolin-2-yl)propanamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: inhibitor, adp-ribosyl transferase, protein-ligand complex, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81751.14

構造登録者

Karlberg, T.,Thorsell, A.G.,Lindgren, A.E.G.,Moche, M.,Brock, J.,Ekblad, T.,Spjut, S.,Elofsson, M.,Schuler, H. (登録日: 2018-05-08, 公開日: 2019-05-22, 最終更新日: 2024-01-17)

• 主引用文献: Karlberg, T.,Thorsell, A.G.,Lindgren, A.E.G.,Ekblad, T.,Spjut, S.,Elofsson, M.,Schuler, H.; Human PARP1 (ARTD1) - Catalytic domain in complex with inhibitor ME0527; To Be Published,

実験手法

X-RAY DIFFRACTION (2.28 Å)