6GGF

Structure of the p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9328

6GGF の概要

分子名称Cellular tumor antigen p53, ZINC ION, [9-ethyl-7-(4-methylthiophen-2-yl)carbazol-3-yl]methyl-methyl-azanium, ... (5 entities in total)
機能のキーワードp53, transcription factor, tumor supressor, cancer therapy, oncogenic mutant, protein misfolding, small-molecule stabilizer, molecular chaperone, dna binding protein
由来する生物種Homo sapiens (Human)
ポリマー鎖数2
分子量合計49955.51
構造登録者
Joerger, A.C.,Bauer, M.R. (登録日: 2018-05-03, 公開日: 2019-05-22)
主引用文献
Jones, R.N.,Bauer, M.R.,Springett, B.,Dingler, F.A.,Verduci, L.,Patel, K.J.,Fersht, A.R.,Joerger, A.C.,Spencer, J.
A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C
to be published,
実験手法
X-RAY DIFFRACTION (1.32000022323 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.15220 0.9% 7.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード