p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9327

Summary for 6GGE

DescriptorCellular tumor antigen p53, ZINC ION, [9-ethyl-7-(5-methylthiophen-2-yl)carbazol-3-yl]methyl-methyl-azanium, ... (4 entities in total)
Functional Keywordsp53, transcription factor, tumor supressor, cancer therapy, oncogenic mutant, protein misfolding, small-molecule stabilizer, molecular chaperone, dna binding protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight49863.41
Joerger, A.C.,Bauer, M.R. (deposition date: 2018-05-03, release date: 2019-05-22, Last modification date: 2019-10-30)
Primary citation
Bauer, M.R.,Jones, R.N.,Tareque, R.K.,Springett, B.,Dingler, F.A.,Verduci, L.,Patel, K.J.,Fersht, A.R.,Joerger, A.C.,Spencer, J.
A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.
Future Med Chem, 11:2491-2504, 2019
PubMed: 31633398 (PDB entries with the same primary citation)
DOI: 10.4155/fmc-2019-0181
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.25000506704 Å)

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.17110 1.2% 6.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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