6GFV

M tuberculosis LpqI

6GFV の概要

• エントリーDOI: 10.2210/pdb6gfv/pdb
• 分子名称: Probable conserved lipoprotein LpqI (2 entities in total)
• 機能のキーワード: peptidoglycan mycobacterium gh3, sugar binding protein
• 由来する生物種: Mycobacterium tuberculosis H37Rv
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70751.94

構造登録者

Moynihan, P.J.,Lovering, A.L. (登録日: 2018-05-02, 公開日: 2019-05-15, 最終更新日: 2024-11-13)

主引用文献

Moynihan, P.J.,Cadby, I.T.,Veerapen, N.,Jankute, M.,Crosatti, M.,Mukamolova, G.V.,Lovering, A.L.,Besra, G.S.
The hydrolase LpqI primes mycobacterial peptidoglycan recycling.
Nat Commun, 10:2647-2647, 2019

PubMed Abstract: Growth and division by most bacteria requires remodelling and cleavage of their cell wall. A byproduct of this process is the generation of free peptidoglycan (PG) fragments known as muropeptides, which are recycled in many model organisms. Bacteria and hosts can harness the unique nature of muropeptides as a signal for cell wall damage and infection, respectively. Despite this critical role for muropeptides, it has long been thought that pathogenic mycobacteria such as Mycobacterium tuberculosis do not recycle their PG. Herein we show that M. tuberculosis and Mycobacterium bovis BCG are able to recycle components of their PG. We demonstrate that the core mycobacterial gene lpqI, encodes an authentic NagZ β-N-acetylglucosaminidase and that it is essential for PG-derived amino sugar recycling via an unusual pathway. Together these data provide a critical first step in understanding how mycobacteria recycle their peptidoglycan.

PubMed: 31201321
DOI: 10.1038/s41467-019-10586-2

実験手法

X-RAY DIFFRACTION (1.96 Å)