6GFT

Antinociceptive evaluation of cyriotoxin-1a, the first toxin purified from Cyriopagopus schioedtei spider venom

6GFT の概要

• エントリーDOI: 10.2210/pdb6gft/pdb
• NMR情報: BMRB: 34267
• 分子名称: cyriotoxin-1a (1 entity in total)
• 機能のキーワード: toxine, spider venom, cyriopagopus schioedtei, toxin
• 由来する生物種: Cyriopagopus schioedtei
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3593.32

構造登録者

Kurz, M. (登録日: 2018-05-02, 公開日: 2019-03-06, 最終更新日: 2024-10-09)

主引用文献

Goncalves, T.C.,Benoit, E.,Kurz, M.,Lucarain, L.,Fouconnier, S.,Combemale, S.,Jaquillard, L.,Schombert, B.,Chambard, J.M.,Boukaiba, R.,Hessler, G.,Bohme, A.,Bialy, L.,Hourcade, S.,Beroud, R.,De Waard, M.,Servent, D.,Partiseti, M.
From identification to functional characterization of cyriotoxin-1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei.
Br.J.Pharmacol., 176:1298-1314, 2019

PubMed Abstract: The Na 1.7 channel is highly expressed in dorsal root ganglia of the sensory nervous system and plays a central role in the pain signalling process. We investigated a library prepared from original venoms of 117 different animals to identify new selective inhibitors of this target.

PubMed: 30784059
DOI: 10.1111/bph.14628

実験手法

SOLUTION NMR