6GEQ

Crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP121A1 in complex with Triazole Pyrazole inhibitor 14a

6GEQ の概要

• エントリーDOI: 10.2210/pdb6geq/pdb
• 分子名称: Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, 1-phenyl-3-pyridin-4-yl-~{N}-(pyridin-4-ylmethyl)pyrazole-4-carboxamide, ... (5 entities in total)
• 機能のキーワード: inhibitor complex p450, antibiotic, oxidoreductase
• 由来する生物種: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44469.87

構造登録者

Levy, C.W. (登録日: 2018-04-27, 公開日: 2019-08-07, 最終更新日: 2024-01-17)

• 主引用文献: Kishk, S.M.,McLean, K.J.,Sood, S.,Smith, D.,Evans, J.W.D.,Helal, M.A.,Gomaa, M.S.,Salama, I.,Mostafa, S.M.,de Carvalho, L.P.S.,Levy, C.W.,Munro, A.W.,Simons, C.; Design and Synthesis of Imidazole and Triazole Pyrazoles asMycobacterium TuberculosisCYP121A1 Inhibitors.; Chemistryopen, 8:995-1011, 2019; PubMed: 31367508; DOI: 10.1002/open.201900227

実験手法

X-RAY DIFFRACTION (1.6 Å)