6GE3

X-ray structure of TEAD4 (wildtype) complexed with YAP (wildtype): The role of residual flexibility and water molecules in the adaptation of a bound intrinsically disordered protein to mutations at a binding interface

6GE3 の概要

• エントリーDOI: 10.2210/pdb6ge3/pdb
• 分子名称: Transcriptional enhancer factor TEF-3, Transcriptional coactivator YAP1, MYRISTIC ACID, ... (5 entities in total)
• 機能のキーワード: transcription factor, co-activator, transcription regulation, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30471.50

構造登録者

Kallen, J. (登録日: 2018-04-25, 公開日: 2018-09-19, 最終更新日: 2018-10-31)

• 主引用文献: Mesrouze, Y.,Bokhovchuk, F.,Izaac, A.,Meyerhofer, M.,Zimmermann, C.,Fontana, P.,Schmelzle, T.,Erdmann, D.,Furet, P.,Kallen, J.,Chene, P.; Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface.; Protein Sci., 27:1810-1820, 2018; PubMed: 30058229; DOI: 10.1002/pro.3493

実験手法

X-RAY DIFFRACTION (1.85 Å)