6G9S

Structural basis for the inhibition of E. coli PBP2

Summary for 6G9S

Entry DOI	10.2210/pdb6g9s/pdb
Related	6G9F 6G9P
Descriptor	Peptidoglycan D,D-transpeptidase MrdA, (3~{R},6~{S})-6-(aminomethyl)-4-(1,3-oxazol-5-yl)-3-(sulfooxyamino)-3,6-dihydro-2~{H}-pyridine-1-carboxylic acid (3 entities in total)
Functional Keywords	penicillin binding protein, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological source	Escherichia coli K-12
Total number of polymer chains	1
Total formula weight	65409.83
Authors	Ruff, M.,Levy, N. (deposition date: 2018-04-11, release date: 2019-05-22, Last modification date: 2024-01-17)
Primary citation	Levy, N.,Bruneau, J.M.,Le Rouzic, E.,Bonnard, D.,Le Strat, F.,Caravano, A.,Chevreuil, F.,Barbion, J.,Chasset, S.,Ledoussal, B.,Moreau, F.,Ruff, M. Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design. J.Med.Chem., 62:4742-4754, 2019 Cited by PubMed: 30995398 DOI: 10.1021/acs.jmedchem.9b00338 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.001 Å)

Structure validation