6G5U

Crystal structure of human carbonic anhydrase isozyme XIII with N-butyl-2,4-dichloro-5-sulfamoyl-benzamide

6G5U の概要

• エントリーDOI: 10.2210/pdb6g5u/pdb
• 分子名称: Carbonic anhydrase 13, ZINC ION, ~{N}-butyl-2,4-bis(chloranyl)-5-sulfamoyl-benzamide, ... (6 entities in total)
• 機能のキーワード: drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60386.20

構造登録者

Smirnov, A.,Manakova, E.,Grazulis, S. (登録日: 2018-03-30, 公開日: 2019-03-13, 最終更新日: 2024-01-17)

• 主引用文献: Zaksauskas, A.,Capkauskaite, E.,Jezepcikas, L.,Linkuviene, V.,Kisonaite, M.,Smirnov, A.,Manakova, E.,Grazulis, S.,Matulis, D.; Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases.; Eur J Med Chem, 156:61-78, 2018; PubMed: 30006175; DOI: 10.1016/j.ejmech.2018.06.059

実験手法

X-RAY DIFFRACTION (1.7 Å)