6G4P

Non-aged form of Torpedo californica acetylcholinesterase inhibited by tabun analog NEDPA bound to uncharged reactivator 2

6G4P の概要

• エントリーDOI: 10.2210/pdb6g4p/pdb
• 分子名称: Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose, ethoxy-~{N},~{N}-dimethyl-phosphonamidic acid, ... (7 entities in total)
• 機能のキーワード: acetylcholinesterase, tabun, nerve agent, hydrolase
• 由来する生物種: Tetronarce californica (Pacific electric ray)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 124186.02

構造登録者

Santoni, G.,De la Mora, E.,de Souza, J.,Silman, I.,Sussman, J.,Baati, R.,Weik, M.,Nachon, F. (登録日: 2018-03-28, 公開日: 2018-08-29, 最終更新日: 2024-01-17)

• 主引用文献: Santoni, G.,de Sousa, J.,de la Mora, E.,Dias, J.,Jean, L.,Sussman, J.L.,Silman, I.,Renard, P.Y.,Brown, R.C.D.,Weik, M.,Baati, R.,Nachon, F.; Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents.; J. Med. Chem., 61:7630-7639, 2018; PubMed: 30125110; DOI: 10.1021/acs.jmedchem.8b00592

実験手法

X-RAY DIFFRACTION (2.83 Å)