6FZU
RORGT (264-518;C455S) IN COMPLEX WITH THE FRAGMENT ("CPD-1") AND RIP140 PEPTIDE AT 1.80A
Summary for 6FZU
Entry DOI | 10.2210/pdb6fzu/pdb |
Descriptor | Nuclear receptor ROR-gamma, Nuclear receptor-interacting protein 1, ~{N}-(3-chloranyl-4-ethoxy-phenyl)ethanamide, ... (4 entities in total) |
Functional Keywords | fbs, nuclear hormone receptor, ligand-binding domain, inverse agonist, signaling protein, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 64545.18 |
Authors | Kallen, J. (deposition date: 2018-03-15, release date: 2018-07-18, Last modification date: 2024-01-17) |
Primary citation | Carcache, D.A.,Vulpetti, A.,Kallen, J.,Mattes, H.,Orain, D.,Stringer, R.,Vangrevelinghe, E.,Wolf, R.M.,Kaupmann, K.,Ottl, J.,Dawson, J.,Cooke, N.G.,Hoegenauer, K.,Billich, A.,Wagner, J.,Guntermann, C.,Hintermann, S. Optimizing a Weakly Binding Fragment into a Potent ROR gamma t Inverse Agonist with Efficacy in an in Vivo Inflammation Model. J. Med. Chem., 61:6724-6735, 2018 Cited by PubMed: 29990434DOI: 10.1021/acs.jmedchem.8b00529 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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