6FYZ
Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor
Summary for 6FYZ
Entry DOI | 10.2210/pdb6fyz/pdb |
Descriptor | Histone deacetylase 4, (2~{S})-2-(2-fluorophenyl)-2-[4-(2-methylpyrimidin-5-yl)phenyl]-~{N}-oxidanyl-ethanamide, ZINC ION, ... (5 entities in total) |
Functional Keywords | hydroxamic acid, cns-penetrant, hdac4 inhibition, class iia hdac inhibitor, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 129866.38 |
Authors | Luckhurst, C.A.,Maillard, M.C.,Dominguez, C. (deposition date: 2018-03-13, release date: 2018-12-05, Last modification date: 2024-01-17) |
Primary citation | Luckhurst, C.A.,Aziz, O.,Beaumont, V.,Burli, R.W.,Breccia, P.,Maillard, M.C.,Haughan, A.F.,Lamers, M.,Leonard, P.,Matthews, K.L.,Raphy, G.,Stott, A.J.,Munoz-Sanjuan, I.,Thomas, B.,Wall, M.,Wishart, G.,Yates, D.,Dominguez, C. Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. Bioorg. Med. Chem. Lett., 29:83-88, 2019 Cited by PubMed: 30463802DOI: 10.1016/j.bmcl.2018.11.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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