6FWZ
Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) (V264G mutant) in complex with UDP-GlcNAc
6FWZ の概要
エントリーDOI | 10.2210/pdb6fwz/pdb |
分子名称 | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, MAGNESIUM ION, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, ... (6 entities in total) |
機能のキーワード | protein glycosylation, integral membrane protein, pnpt, congenital myasthenic syndrome, antibiotic, structural genomics, structural genomics consortium, sgc, transferase |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 47552.37 |
構造登録者 | Pike, A.C.W.,Dong, Y.Y.,Chu, A.,Tessitore, A.,Goubin, S.,Dong, L.,Mukhopadhyay, S.,Mahajan, P.,Chalk, R.,Berridge, G.,Wang, D.,Kupinska, K.,Belaya, K.,Beeson, D.,Burgess-Brown, N.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Carpenter, E.P.,Structural Genomics Consortium (SGC) (登録日: 2018-03-07, 公開日: 2018-07-25, 最終更新日: 2024-01-17) |
主引用文献 | Dong, Y.Y.,Wang, H.,Pike, A.C.W.,Cochrane, S.A.,Hamedzadeh, S.,Wyszynski, F.J.,Bushell, S.R.,Royer, S.F.,Widdick, D.A.,Sajid, A.,Boshoff, H.I.,Park, Y.,Lucas, R.,Liu, W.M.,Lee, S.S.,Machida, T.,Minall, L.,Mehmood, S.,Belaya, K.,Liu, W.W.,Chu, A.,Shrestha, L.,Mukhopadhyay, S.M.M.,Strain-Damerell, C.,Chalk, R.,Burgess-Brown, N.A.,Bibb, M.J.,Barry Iii, C.E.,Robinson, C.V.,Beeson, D.,Davis, B.G.,Carpenter, E.P. Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design. Cell, 175:1045-1058.e16, 2018 Cited by PubMed: 30388443DOI: 10.1016/j.cell.2018.10.037 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.1 Å) |
構造検証レポート
検証レポート(詳細版)
をダウンロード
![ダウンロード](/newweb/media/icons/dl.png)