6FWB

Crystal structure of Mat2A at 1.79 Angstron resolution

Summary for 6FWB

• Entry DOI: 10.2210/pdb6fwb/pdb
• Descriptor: S-adenosylmethionine synthase isoform type-2, SULFATE ION, TETRAETHYLENE GLYCOL, ... (6 entities in total)
• Functional Keywords: s-adenosylmethionine synthetase 2, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 185502.27

Authors

Zhou, A.,Wei, Z.,Bai, J.,Wang, H. (deposition date: 2018-03-06, release date: 2019-03-27, Last modification date: 2024-05-08)

Primary citation

Bai, J.,Gao, Y.,Chen, L.,Yin, Q.,Lou, F.,Wang, Z.,Xu, Z.,Zhou, H.,Li, Q.,Cai, W.,Sun, Y.,Niu, L.,Wang, H.,Wei, Z.,Lu, S.,Zhou, A.,Zhang, J.,Wang, H.
Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes.
Ebiomedicine, 39:575-590, 2019

PubMed Abstract: Psoriasis is a common chronic inflammatory skin disease which lacks effective strategies for the treatment. Natural compounds with biological activities are good tools to identify new targets with therapeutic potentials. Acetyl-11-keto-β-boswellic acid (AKBA) is the most bioactive ingredient of boswellic acids, a group of compounds with anti-inflammatory and anti-cancer properties. Target identification of AKBA and metabolomics analysis of psoriasis helped to elucidate the molecular mechanism underlying its effect, and provide new target(s) to treat the disease.

PubMed: 30591370
DOI: 10.1016/j.ebiom.2018.12.036

Experimental method

X-RAY DIFFRACTION (1.79 Å)