6FW0

Crystal structure of human monoamine oxidase B (MAO B) in complex with chlorophenyl-chromone-carboxamide

Summary for 6FW0

Entry DOI	10.2210/pdb6fw0/pdb
Descriptor	Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, ~{N}-(3-chlorophenyl)-4-oxidanylidene-chromene-3-carboxamide, ... (6 entities in total)
Functional Keywords	parkinson's disease, drug design, chromone, inhibitor, flavoprotein
Biological source	Homo sapiens (Human)
Cellular location	Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338
Total number of polymer chains	2
Total formula weight	120703.27
Authors	Reis, J.,Manzella, N.,Cagide, F.,Mialet-Perez, J.,Uriarte, E.,Parini, A.,Borges, F.,Binda, C. (deposition date: 2018-03-05, release date: 2018-04-25, Last modification date: 2024-01-17)
Primary citation	Reis, J.,Manzella, N.,Cagide, F.,Mialet-Perez, J.,Uriarte, E.,Parini, A.,Borges, F.,Binda, C. Tight-Binding Inhibition of Human Monoamine Oxidase B by Chromone Analogs: A Kinetic, Crystallographic, and Biological Analysis. J. Med. Chem., 61:4203-4212, 2018 Cited by PubMed: 29648817 DOI: 10.1021/acs.jmedchem.8b00357 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation