6FW0

Crystal structure of human monoamine oxidase B (MAO B) in complex with chlorophenyl-chromone-carboxamide

6FW0 の概要

• エントリーDOI: 10.2210/pdb6fw0/pdb
• 分子名称: Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, ~{N}-(3-chlorophenyl)-4-oxidanylidene-chromene-3-carboxamide, ... (6 entities in total)
• 機能のキーワード: parkinson's disease, drug design, chromone, inhibitor, flavoprotein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 120703.27

構造登録者

Reis, J.,Manzella, N.,Cagide, F.,Mialet-Perez, J.,Uriarte, E.,Parini, A.,Borges, F.,Binda, C. (登録日: 2018-03-05, 公開日: 2018-04-25, 最終更新日: 2024-01-17)

• 主引用文献: Reis, J.,Manzella, N.,Cagide, F.,Mialet-Perez, J.,Uriarte, E.,Parini, A.,Borges, F.,Binda, C.; Tight-Binding Inhibition of Human Monoamine Oxidase B by Chromone Analogs: A Kinetic, Crystallographic, and Biological Analysis.; J. Med. Chem., 61:4203-4212, 2018; PubMed: 29648817; DOI: 10.1021/acs.jmedchem.8b00357

実験手法

X-RAY DIFFRACTION (1.6 Å)