6FTY

COMPLEMENT FACTOR D COMPLEXED WITH COMPOUND 5

6FTY の概要

• エントリーDOI: 10.2210/pdb6fty/pdb
• 分子名称: Complement factor D, 4-[[(5~{S},7~{R})-3-azanyl-1-adamantyl]carbonylamino]-1~{H}-indole-2-carboxamide, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: serine protease, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25183.65

構造登録者

Ostermann, N. (登録日: 2018-02-26, 公開日: 2018-06-06, 最終更新日: 2024-01-17)

• 主引用文献: Vulpetti, A.,Ostermann, N.,Randl, S.,Yoon, T.,Mac Sweeney, A.,Cumin, F.,Lorthiois, E.,Rudisser, S.,Erbel, P.,Maibaum, J.; Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D.; ACS Med Chem Lett, 9:490-495, 2018; PubMed: 29795765; DOI: 10.1021/acsmedchemlett.8b00104

実験手法

X-RAY DIFFRACTION (1.67 Å)