6FTP

Crystal form 1 of Alpha1-antichymotrypsin variant DBS-II-allo: an allosterically modulated drug-binding serpin for doxorubicin

Summary for 6FTP

Entry DOI	10.2210/pdb6ftp/pdb
Related	5OM8
Descriptor	Alpha-1-antichymotrypsin, 1,2-ETHANEDIOL, DOXORUBICIN, ... (5 entities in total)
Functional Keywords	serpin, alpha1-antichymotrypsin, doxorubicin-binding protein, allosterically triggered drug release, transport protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	47436.82
Authors	Schmidt, K.,Muller, Y.A. (deposition date: 2018-02-22, release date: 2018-05-23, Last modification date: 2024-01-17)
Primary citation	Schmidt, K.,Gardill, B.R.,Kern, A.,Kirchweger, P.,Borsch, M.,Muller, Y.A. Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein. Proc. Natl. Acad. Sci. U.S.A., 115:5744-5749, 2018 Cited by PubMed: 29760101 DOI: 10.1073/pnas.1716666115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation