6FTN

mPI3Kd IN COMPLEX WITH AZ2

Summary for 6FTN

Entry DOI	10.2210/pdb6ftn/pdb
Descriptor	Phosphor inositol 3 kinase, ~{N}-[5-[2-[(1~{S})-1-cyclopropylethyl]-7-methyl-1-oxidanylidene-3~{H}-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]ethanamide (3 entities in total)
Functional Keywords	mi3kd, transferase
Biological source	Mus musculus (house mouse)
Total number of polymer chains	1
Total formula weight	108136.09
Authors	Petersen, J. (deposition date: 2018-02-22, release date: 2018-06-20, Last modification date: 2018-07-11)
Primary citation	Pemberton, N.,Mogemark, M.,Arlbrandt, S.,Bold, P.,Cox, R.J.,Gardelli, C.,Holden, N.S.,Karabelas, K.,Karlsson, J.,Lever, S.,Li, X.,Lindmark, H.,Norberg, M.,Perry, M.W.D.,Petersen, J.,Rodrigo Blomqvist, S.,Thomas, M.,Tyrchan, C.,Westin Eriksson, A.,Zlatoidsky, P.,Oster, L. Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-gamma Inhibitors. J. Med. Chem., 61:5435-5441, 2018 Cited by PubMed: 29852070 DOI: 10.1021/acs.jmedchem.8b00447 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation