6FSY

Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand

6FSY の概要

• エントリーDOI: 10.2210/pdb6fsy/pdb
• 分子名称: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(~{R})-oxidanyl(pyridin-3-yl)methyl]phenol, ... (4 entities in total)
• 機能のキーワード: bromodomain, ligand, transcription, isoxazole, structural genomics, structural genomics consortium, sgc
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15519.84

構造登録者

Filippakopoulos, P.,Picaud, S.,Conway, S.J.,Pike, A.C.W.,Krojer, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Structural Genomics Consortium (SGC) (登録日: 2018-02-20, 公開日: 2018-04-18, 最終更新日: 2024-01-17)

• 主引用文献: Jennings, L.E.,Schiedel, M.,Hewings, D.S.,Picaud, S.,Laurin, C.M.C.,Bruno, P.A.,Bluck, J.P.,Scorah, A.R.,See, L.,Reynolds, J.K.,Moroglu, M.,Mistry, I.N.,Hicks, A.,Guzanov, P.,Clayton, J.,Evans, C.N.G.,Stazi, G.,Biggin, P.C.,Mapp, A.K.,Hammond, E.M.,Humphreys, P.G.,Filippakopoulos, P.,Conway, S.J.; BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.; Bioorg.Med.Chem., 26:2937-2957, 2018; PubMed: 29776834; DOI: 10.1016/j.bmc.2018.05.003

実験手法

X-RAY DIFFRACTION (1.34 Å)