6FSF

Crystal structure of the tandem PX-PH-domains of Bem3 from Saccharomyces cerevisiae

6FSF の概要

• エントリーDOI: 10.2210/pdb6fsf/pdb
• 分子名称: GTPase-activating protein BEM3 (2 entities in total)
• 機能のキーワード: bem3, px domain, ph domain, phox, pleckstrin homology, phosphatidylinositol phosphates, pip, endocytosis
• 由来する生物種: Saccharomyces cerevisiae S288C
• 細胞内の位置: Cytoplasm: P32873
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30739.94

構造登録者

Ali, I.,Eu, S.,Koch, D.,Bleimling, N.,Goody, R.S.,Mueller, M.P. (登録日: 2018-02-19, 公開日: 2018-05-02, 最終更新日: 2024-05-08)

主引用文献

Ali, I.,Eu, S.,Koch, D.,Bleimling, N.,Goody, R.S.,Muller, M.P.
Structure of the tandem PX-PH domains of Bem3 from Saccharomyces cerevisiae.
Acta Crystallogr F Struct Biol Commun, 74:315-321, 2018

PubMed Abstract: The structure of the tandem lipid-binding PX and pleckstrin-homology (PH) domains of the Cdc42 GTPase-activating protein Bem3 from Saccharomyces cerevisiae (strain S288c) has been determined to a resolution of 2.2 Å (R = 21.1%, R = 23.4%). It shows that the domains adopt a relative orientation that enables them to simultaneously bind to a membrane and suggests possible cooperativity in membrane binding.

PubMed: 29718000
DOI: 10.1107/S2053230X18005915

実験手法

X-RAY DIFFRACTION (2.2 Å)