6FOZ

The crystal structure of P.fluorescens Kynurenine 3-monooxygenase (KMO) in complex with competitive inhibitor No. 13

Summary for 6FOZ

Entry DOI	10.2210/pdb6foz/pdb
Descriptor	Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, 5-(3,4-dichlorophenyl)furan-2-carboxylic acid, ... (4 entities in total)
Functional Keywords	inhibitor, oxidoreductase
Biological source	Pseudomonas fluorescens
Total number of polymer chains	2
Total formula weight	103301.89
Authors	Levy, C.W.,Leys, D. (deposition date: 2018-02-08, release date: 2019-08-21, Last modification date: 2024-05-01)
Primary citation	Zhang, S.,Sakuma, M.,Deora, G.S.,Levy, C.W.,Klausing, A.,Breda, C.,Read, K.D.,Edlin, C.D.,Ross, B.P.,Wright Muelas, M.,Day, P.J.,O'Hagan, S.,Kell, D.B.,Schwarcz, R.,Leys, D.,Heyes, D.J.,Giorgini, F.,Scrutton, N.S. A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites. Commun Biol, 2:271-271, 2019 Cited by PubMed: 31372510 DOI: 10.1038/s42003-019-0520-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation