6FOZ

The crystal structure of P.fluorescens Kynurenine 3-monooxygenase (KMO) in complex with competitive inhibitor No. 13

6FOZ の概要

• エントリーDOI: 10.2210/pdb6foz/pdb
• 分子名称: Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, 5-(3,4-dichlorophenyl)furan-2-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: inhibitor, oxidoreductase
• 由来する生物種: Pseudomonas fluorescens
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 103301.89

構造登録者

Levy, C.W.,Leys, D. (登録日: 2018-02-08, 公開日: 2019-08-21, 最終更新日: 2024-05-01)

• 主引用文献: Zhang, S.,Sakuma, M.,Deora, G.S.,Levy, C.W.,Klausing, A.,Breda, C.,Read, K.D.,Edlin, C.D.,Ross, B.P.,Wright Muelas, M.,Day, P.J.,O'Hagan, S.,Kell, D.B.,Schwarcz, R.,Leys, D.,Heyes, D.J.,Giorgini, F.,Scrutton, N.S.; A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites.; Commun Biol, 2:271-271, 2019; PubMed: 31372510; DOI: 10.1038/s42003-019-0520-5

実験手法

X-RAY DIFFRACTION (2.15 Å)