6FNM

Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase with Dasatinib

Summary for 6FNM

Entry DOI	10.2210/pdb6fnm/pdb
Descriptor	Ephrin type-B receptor 4, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE (3 entities in total)
Functional Keywords	inhibitor, complex, protein tyrosine kinase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33976.36
Authors	Kudlinzki, D.,Troester, A.,Witt, K.,Linhard, V.L.,Saxena, K.,Schwalbe, H. (deposition date: 2018-02-04, release date: 2018-08-08, Last modification date: 2024-01-17)
Primary citation	Troster, A.,Heinzlmeir, S.,Berger, B.T.,Gande, S.L.,Saxena, K.,Sreeramulu, S.,Linhard, V.,Nasiri, A.H.,Bolte, M.,Muller, S.,Kuster, B.,Medard, G.,Kudlinzki, D.,Schwalbe, H. NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. ChemMedChem, 13:1629-1633, 2018 Cited by PubMed: 29928781 DOI: 10.1002/cmdc.201800398 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.157 Å)

Structure validation