6FNM

Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase with Dasatinib

6FNM の概要

• エントリーDOI: 10.2210/pdb6fnm/pdb
• 分子名称: Ephrin type-B receptor 4, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE (3 entities in total)
• 機能のキーワード: inhibitor, complex, protein tyrosine kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33976.36

構造登録者

Kudlinzki, D.,Troester, A.,Witt, K.,Linhard, V.L.,Saxena, K.,Schwalbe, H. (登録日: 2018-02-04, 公開日: 2018-08-08, 最終更新日: 2024-01-17)

• 主引用文献: Troster, A.,Heinzlmeir, S.,Berger, B.T.,Gande, S.L.,Saxena, K.,Sreeramulu, S.,Linhard, V.,Nasiri, A.H.,Bolte, M.,Muller, S.,Kuster, B.,Medard, G.,Kudlinzki, D.,Schwalbe, H.; NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.; ChemMedChem, 13:1629-1633, 2018; PubMed: 29928781; DOI: 10.1002/cmdc.201800398

実験手法

X-RAY DIFFRACTION (1.157 Å)