6FMU

Thioredoxin glutathione reductase from Schistosome mansoni in complex with 2-[4-(4-amino-butyl)-piperazin-1-yl]-ethanol

6FMU の概要

• エントリーDOI: 10.2210/pdb6fmu/pdb
• 分子名称: Thioredoxin glutathione reductase, FLAVIN-ADENINE DINUCLEOTIDE, 2-[4-(4-azanylbutyl)piperazin-1-yl]ethanol, ... (5 entities in total)
• 機能のキーワード: fragment, allosteric pocket, schistosomiasis, fad/nad linked reductase, flavoprotein
• 由来する生物種: Schistosoma mansoni
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 66198.18

構造登録者

Silvestri, I.,Fata, F.,MIele, A.E.,Boumis, G.,Williams, D.L.,Angelucci, F. (登録日: 2018-02-02, 公開日: 2018-06-06, 最終更新日: 2024-01-17)

• 主引用文献: Silvestri, I.,Lyu, H.,Fata, F.,Boumis, G.,Miele, A.E.,Ardini, M.,Ippoliti, R.,Bellelli, A.,Jadhav, A.,Lea, W.A.,Simeonov, A.,Cheng, Q.,Arner, E.S.J.,Thatcher, G.R.J.,Petukhov, P.A.,Williams, D.L.,Angelucci, F.; Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry.; ACS Chem. Biol., 13:2190-2202, 2018; PubMed: 29800515; DOI: 10.1021/acschembio.8b00349

実験手法

X-RAY DIFFRACTION (1.8 Å)