6FLI
The active form of a pentameric ion channel (sTeLIC) gated by alkaline pH - Co-crystallization with 4-bromo cinnamic acid
Summary for 6FLI
Entry DOI | 10.2210/pdb6fli/pdb |
Related | 6FL9 |
Descriptor | Cys-loop ligand-gated ion channel, nonyl beta-D-glucopyranoside, 3-(4-bromophenyl)propanoic acid, ... (4 entities in total) |
Functional Keywords | pentameric ligand-gated ion channel., membrane protein |
Biological source | endosymbiont of Tevnia jerichonana (vent Tica) |
Total number of polymer chains | 5 |
Total formula weight | 189231.43 |
Authors | Hu, H.,Delarue, M. (deposition date: 2018-01-26, release date: 2018-05-16, Last modification date: 2024-05-08) |
Primary citation | Hu, H.,Nemecz, A.,Van Renterghem, C.,Fourati, Z.,Sauguet, L.,Corringer, P.J.,Delarue, M. Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation. Proc. Natl. Acad. Sci. U.S.A., 115:E3959-E3968, 2018 Cited by PubMed: 29632192DOI: 10.1073/pnas.1717700115 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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