6FJL

Structure of IbpS from Dickeya dadantii

6FJL の概要

• エントリーDOI: 10.2210/pdb6fjl/pdb
• 関連するPDBエントリー: 6HHB
• 分子名称: ABC-type Fe3+ transport system, periplasmic component, ACETATE ION, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: substrate binding protein bacterial effector venus fly-trap, metal binding protein
• 由来する生物種: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 155619.07

構造登録者

Gueguen-Chaignon, V.,Condemine, G.,Terradot, L. (登録日: 2018-01-22, 公開日: 2019-02-06, 最終更新日: 2024-05-08)

主引用文献

Liu, L.,Gueguen-Chaignon, V.,Goncalves, I.R.,Rascle, C.,Rigault, M.,Dellagi, A.,Loisel, E.,Poussereau, N.,Rodrigue, A.,Terradot, L.,Condemine, G.
A secreted metal-binding protein protects necrotrophic phytopathogens from reactive oxygen species.
Nat Commun, 10:4853-4853, 2019

PubMed Abstract: Few secreted proteins involved in plant infection common to necrotrophic bacteria, fungi and oomycetes have been identified except for plant cell wall-degrading enzymes. Here we study a family of iron-binding proteins that is present in Gram-negative and Gram-positive bacteria, fungi, oomycetes and some animals. Homolog proteins in the phytopathogenic bacterium Dickeya dadantii (IbpS) and the fungal necrotroph Botrytis cinerea (BcIbp) are involved in plant infection. IbpS is secreted, can bind iron and copper, and protects the bacteria against HO-induced death. Its 1.7 Å crystal structure reveals a classical Venus Fly trap fold that forms dimers in solution and in the crystal. We propose that secreted Ibp proteins binds exogenous metals and thus limit intracellular metal accumulation and ROS formation in the microorganisms.

PubMed: 31649262
DOI: 10.1038/s41467-019-12826-x

実験手法

X-RAY DIFFRACTION (1.70000035298 Å)