6FG6

Crystal Structure of BAZ2A bromodomain in complex with 1-methylpyridinone compound 1

Summary for 6FG6

Entry DOI	10.2210/pdb6fg6/pdb
Descriptor	Bromodomain adjacent to zinc finger domain protein 2A, ~{N}-(2-azanylethyl)-1-methyl-6-oxidanylidene-pyridine-3-carboxamide (3 entities in total)
Functional Keywords	four helical bundle, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	12576.14
Authors	Dalle Vedove, A.,Spiliotopoulos, D.,Lolli, G.,Caflisch, A. (deposition date: 2018-01-10, release date: 2018-05-30, Last modification date: 2024-01-17)
Primary citation	Dalle Vedove, A.,Spiliotopoulos, D.,D'Agostino, V.G.,Marchand, J.R.,Unzue, A.,Nevado, C.,Lolli, G.,Caflisch, A. Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains. ChemMedChem, 13:1479-1487, 2018 Cited by PubMed: 29770599 DOI: 10.1002/cmdc.201800234 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.401 Å)

Structure validation