6FG6

Crystal Structure of BAZ2A bromodomain in complex with 1-methylpyridinone compound 1

6FG6 の概要

• エントリーDOI: 10.2210/pdb6fg6/pdb
• 分子名称: Bromodomain adjacent to zinc finger domain protein 2A, ~{N}-(2-azanylethyl)-1-methyl-6-oxidanylidene-pyridine-3-carboxamide (3 entities in total)
• 機能のキーワード: four helical bundle, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12576.14

構造登録者

Dalle Vedove, A.,Spiliotopoulos, D.,Lolli, G.,Caflisch, A. (登録日: 2018-01-10, 公開日: 2018-05-30, 最終更新日: 2024-01-17)

• 主引用文献: Dalle Vedove, A.,Spiliotopoulos, D.,D'Agostino, V.G.,Marchand, J.R.,Unzue, A.,Nevado, C.,Lolli, G.,Caflisch, A.; Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains.; ChemMedChem, 13:1479-1487, 2018; PubMed: 29770599; DOI: 10.1002/cmdc.201800234

実験手法

X-RAY DIFFRACTION (2.401 Å)