6FFJ

Anti-tumor antibody 14F7-derived single chain fragment variable (scFv)

Summary for 6FFJ

Entry DOI	10.2210/pdb6ffj/pdb
Descriptor	14F7-derived scFv (2 entities in total)
Functional Keywords	ganglioside, scfv, antibody fragment, single chain fragment variable, immuno therapy, 14f7, antitumor protein, gm3
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	112464.95
Authors	Bjerregaard-Andersen, K.,Heggelund, J.E.,Krengel, U. (deposition date: 2018-01-08, release date: 2018-08-15, Last modification date: 2024-01-17)
Primary citation	Bjerregaard-Andersen, K.,Johannesen, H.,Abdel-Rahman, N.,Heggelund, J.E.,Hoas, H.M.,Abraha, F.,Bousquet, P.A.,Hoydahl, L.S.,Burschowsky, D.,Rojas, G.,Oscarson, S.,Loset, G.A.,Krengel, U. Crystal structure of an L chain optimised 14F7 anti-ganglioside Fv suggests a unique tumour-specificity through an unusual H-chain CDR3 architecture. Sci Rep, 8:10836-10836, 2018 Cited by PubMed: 30022069 DOI: 10.1038/s41598-018-28918-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation