6FFJ
Anti-tumor antibody 14F7-derived single chain fragment variable (scFv)
Summary for 6FFJ
Entry DOI | 10.2210/pdb6ffj/pdb |
Descriptor | 14F7-derived scFv (2 entities in total) |
Functional Keywords | ganglioside, scfv, antibody fragment, single chain fragment variable, immuno therapy, 14f7, antitumor protein, gm3 |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 112464.95 |
Authors | Bjerregaard-Andersen, K.,Heggelund, J.E.,Krengel, U. (deposition date: 2018-01-08, release date: 2018-08-15, Last modification date: 2024-01-17) |
Primary citation | Bjerregaard-Andersen, K.,Johannesen, H.,Abdel-Rahman, N.,Heggelund, J.E.,Hoas, H.M.,Abraha, F.,Bousquet, P.A.,Hoydahl, L.S.,Burschowsky, D.,Rojas, G.,Oscarson, S.,Loset, G.A.,Krengel, U. Crystal structure of an L chain optimised 14F7 anti-ganglioside Fv suggests a unique tumour-specificity through an unusual H-chain CDR3 architecture. Sci Rep, 8:10836-10836, 2018 Cited by PubMed: 30022069DOI: 10.1038/s41598-018-28918-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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