6FE4

Crystal structure of the complex between Shiga toxin Stx2 B subunit and neutralising Nb113

Summary for 6FE4

• Entry DOI: 10.2210/pdb6fe4/pdb
• Descriptor: Shiga-like toxin 2 subunit B, Nb113 (3 entities in total)
• Functional Keywords: toxin, complex, nanobody, shiga
• Biological source: Enterobacteria phage 933W (Bacteriophage 933W); More
• Cellular location: Secreted: P09386
• Total number of polymer chains: 10
• Total formula weight: 104475.11

Authors

Bernedo, R.,Muyldermans, S.,Sterckx, Y.G.J. (deposition date: 2017-12-29, release date: 2018-03-07, Last modification date: 2024-11-13)

Primary citation

Bernedo-Navarro, R.A.,Romao, E.,Yano, T.,Pinto, J.,De Greve, H.,Sterckx, Y.G.,Muyldermans, S.
Structural Basis for the Specific Neutralization of Stx2a with a Camelid Single Domain Antibody Fragment.
Toxins (Basel), 10:-, 2018

PubMed Abstract: Shiga toxin-producing (STEC) are a subset of pathogens leading to illnesses such as diarrhea, hemolytic uremic syndrome and even death. The Shiga toxins are the main virulence factors and divided in two groups: Stx1 and Stx2, of which the latter is more frequently associated with severe pathologies in humans.

PubMed: 29494518
DOI: 10.3390/toxins10030108

Experimental method

X-RAY DIFFRACTION (3 Å)