6FE4

Crystal structure of the complex between Shiga toxin Stx2 B subunit and neutralising Nb113

6FE4 の概要

• エントリーDOI: 10.2210/pdb6fe4/pdb
• 分子名称: Shiga-like toxin 2 subunit B, Nb113 (3 entities in total)
• 機能のキーワード: toxin, complex, nanobody, shiga
• 由来する生物種: Enterobacteria phage 933W (Bacteriophage 933W); 詳細
• 細胞内の位置: Secreted: P09386
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 104475.11

構造登録者

Bernedo, R.,Muyldermans, S.,Sterckx, Y.G.J. (登録日: 2017-12-29, 公開日: 2018-03-07, 最終更新日: 2024-11-13)

主引用文献

Bernedo-Navarro, R.A.,Romao, E.,Yano, T.,Pinto, J.,De Greve, H.,Sterckx, Y.G.,Muyldermans, S.
Structural Basis for the Specific Neutralization of Stx2a with a Camelid Single Domain Antibody Fragment.
Toxins (Basel), 10:-, 2018

PubMed Abstract: Shiga toxin-producing (STEC) are a subset of pathogens leading to illnesses such as diarrhea, hemolytic uremic syndrome and even death. The Shiga toxins are the main virulence factors and divided in two groups: Stx1 and Stx2, of which the latter is more frequently associated with severe pathologies in humans.

PubMed: 29494518
DOI: 10.3390/toxins10030108

実験手法

X-RAY DIFFRACTION (3 Å)